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Molecular Syntax

Meaning

Molecular syntax refers to the specific, ordered arrangement and combination of chemical features on a signaling molecule that uniquely determines its biological message and its precise interaction with a corresponding receptor. Just as grammar dictates the meaning of a sentence, the syntax of a molecule—including its stereochemistry, functional groups, and three-dimensional shape—dictates its binding affinity and downstream biological effect. Understanding this molecular syntax is critical for accurately predicting hormonal activity and designing highly selective therapeutic ligands in clinical practice.