A set of structured clinical and physiological interventions designed to address and correct accumulated damage to the body’s fundamental biological molecules, including DNA, proteins, and lipids. These protocols are essential for maintaining cellular integrity and preventing the age-related accumulation of molecular debris and errors. They represent a targeted effort to sustain the fidelity of cellular components.
Origin
The term originates from the study of molecular pathology and aging theory, which posits that the accumulation of molecular damage is a primary driver of senescence. Repair protocols refer to the systematic application of methods to enhance the body’s intrinsic repair systems.
Mechanism
These protocols operate by enhancing endogenous repair pathways, such as the various DNA repair mechanisms (e.g., nucleotide excision repair, base excision repair) and the protein quality control system, including the ubiquitin-proteasome system and autophagy. Specific compounds can act as cofactors or direct activators for repair enzymes, boosting their efficiency. By minimizing the burden of damaged molecules, these protocols reduce cellular stress and maintain the functional capacity of organelles like mitochondria.
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