Molecular Repair Cascades encompass the complex, multi-step intracellular processes activated to correct damage to DNA, proteins, or cellular organelles resulting from normal metabolic activity or external insults. Within hormonal health, these cascades are vital for maintaining cellular integrity against oxidative stress induced by metabolic shifts. We are referring to the body’s inherent machinery for damage control.
Origin
This concept is derived from molecular biology and cell signaling research, describing the sequential activation of enzymes and signaling proteins following an insult. It recognizes that cellular resilience depends on coordinated, cascading responses rather than single-step fixes. The term implies a programmed, efficient response system.
Mechanism
Key cascades involve DNA repair mechanisms like nucleotide excision repair or base excision repair, often regulated by factors such as PARP activation. Furthermore, the autophagy-lysosomal pathway acts as a major cascade for clearing damaged mitochondria and aggregated proteins. Hormonal status significantly influences the initiation and efficiency of these repair processes, often through transcription factor modulation.
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