What is the Origin of Molecular Repair?

The concept is rooted in the foundational discoveries of molecular biology and genetics, particularly the elucidation of DNA repair pathways in the mid-20th century. The clinical application of the term arose in the longevity and regenerative medicine fields, emphasizing the therapeutic potential of actively supporting these endogenous repair mechanisms to extend healthspan.

What is the Mechanism of Molecular Repair?

The mechanisms are diverse, including enzymatic pathways like nucleotide excision repair (NER) and base excision repair (BER) for correcting DNA lesions. For proteins, the mechanism involves chaperone proteins that assist in proper folding and the ubiquitin-proteasome system that tags and degrades misfolded or damaged proteins. Clinical strategies often involve supplying precursors or cofactors, such as NAD+, to enhance the efficiency of these energy-intensive repair processes.

Molecular Repair

Meaning

Molecular Repair is the intrinsic biological process and the clinical goal of restoring damaged macromolecules, such as DNA, proteins, and lipids, to their correct functional state. This continuous process is essential for maintaining cellular integrity and preventing the accumulation of damage that drives aging and chronic disease. Effective molecular repair systems are a fundamental indicator of cellular health and resilience.

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