Therapeutic application involving the precise administration of signaling molecules, such as peptides or specific hormone precursors, to correct deficiencies or modulate receptor activity at the cellular level. This therapy leverages the body’s intrinsic communication system to elicit targeted physiological responses. It focuses on restoring precise molecular signaling fidelity.
Origin
The term merges ‘molecular messenger,’ referring to hormones, neurotransmitters, or peptides that carry biological information, with ‘therapy,’ indicating a medical intervention. This concept is highly relevant in peptide therapeutics and targeted endocrine support. It reflects a granular approach to physiological management.
Mechanism
The mechanism involves the peptide binding with high specificity to cognate receptors, often on the pituitary or target tissues, leading to the release of downstream hormones or activation of intracellular cascades. For instance, administering a growth hormone-releasing peptide mimics the action of GHRH, prompting the pituitary to secrete growth hormone. Efficacy is contingent upon the peptide’s stability, bioavailability, and the presence of functional target receptors.
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