The sequential and often amplifying transmission of signals within and between cells, mediated by specific molecules such as hormones, neurotransmitters, and cytokines. These cascades are fundamental to nearly all physiological processes, translating an initial external stimulus into a coordinated cellular response. Hormonal health relies on the flawless operation of these intricate molecular communication pathways.
Origin
The term is rooted in cellular and molecular biology, where a ‘cascade’ describes a multiplying chain reaction, and ‘molecular messengers’ are the signaling molecules like hormones or secondary messengers. It is a precise descriptor for the complex, hierarchical nature of biological communication. This concept is central to understanding how the body maintains homeostasis.
Mechanism
A hormone binds to a specific receptor on the cell surface or inside the cell, initiating a sequence of intracellular events involving enzymes and second messenger molecules. This process, often through phosphorylation or dephosphorylation, ultimately leads to a change in gene expression or cellular function. The mechanism allows a small initial signal to produce a large, coordinated biological effect.
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