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Molecular Memory Persistence

Meaning

Molecular Memory Persistence describes the cellular capacity to retain a record of past environmental exposures, transcriptional states, or stress events through stable, non-genetic modifications. This form of cellular memory is primarily stored via epigenetic marks, such as DNA methylation patterns and chromatin structure, that are maintained across multiple cell divisions. This persistence influences a cell’s long-term functional behavior and its response to future stimuli. It is the molecular record of a cell’s history.