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Molecular Mechanisms of Stress

Meaning

Molecular Mechanisms of Stress describe the intricate cascade of intracellular and intercellular signaling events that occur in response to a physical or psychological stressor, culminating in a coordinated physiological adaptation. These mechanisms are largely governed by the neuroendocrine system, involving the activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis and the Sympathetic Nervous System (SNS). Understanding these pathways at the molecular level is critical for addressing the long-term health consequences of chronic stress.