A therapeutic framework focused on targeting and optimizing the specific cellular and biochemical pathways that directly influence the rate of biological aging and the maintenance of healthspan. This strategy involves interventions designed to modulate fundamental processes like DNA repair, telomere maintenance, cellular senescence, and mitochondrial function at the molecular level. It represents the most advanced, root-cause approach to extending vitality and delaying age-related decline and pathology.
Origin
This term originates from the burgeoning field of Geroscience, which views aging as a treatable condition driven by identifiable molecular mechanisms, not an inevitability. The strategy integrates knowledge from genetics, epigenetics, and metabolism to create actionable clinical protocols for longevity. It is a direct evolution from general wellness to precision, science-backed anti-aging medicine and intervention.
Mechanism
The strategy operates by utilizing specific compounds, dietary regimens, and lifestyle interventions that act as modulators of key longevity pathways, such as mTOR, AMPK, and the sirtuins. The mechanism includes enhancing autophagy to clear damaged cellular components, improving mitochondrial efficiency for cleaner energy production, and protecting the genome from oxidative damage. The ultimate goal is to optimize the molecular machinery of the cell to resist age-related pathology and maintain functional integrity.
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