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Molecular Fragility

Meaning

Molecular Fragility describes the state of increased susceptibility of essential biological macromolecules, such as DNA, proteins, and lipids, to damage, denaturation, or functional impairment due to internal or external stressors. This heightened vulnerability is a hallmark of cellular aging and disease, reflecting a compromised ability to maintain structural integrity and execute repair mechanisms. In the context of hormonal health, it can manifest as receptor desensitization or impaired enzyme function, directly affecting signal transduction and metabolic pathways. It is a fundamental concept underlying the progressive loss of homeostatic capacity with age.