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Molecular Error Correction

Meaning

Molecular error correction refers to the intricate, endogenous cellular processes designed to detect, repair, and prevent damage to critical biological macromolecules, primarily DNA and proteins. This essential function includes DNA repair mechanisms that fix genetic mutations and chaperone proteins that ensure correct protein folding, preventing the accumulation of toxic aggregates. Efficient error correction is fundamental to maintaining genomic stability and proteostasis, acting as a primary defense against cellular senescence and age-related disease. Impairment in this system is a hallmark of biological aging.