What is the Origin of Molecular Erosion?

The terminology is a metaphorical condensation of several established scientific theories of aging, including the free radical theory and the DNA damage theory. The term 'Erosion' powerfully conveys the irreversible, wear-and-tear nature of this biological degradation. It serves as a unifying concept to explain the necessity of interventions that promote repair and maintenance.

What is the Mechanism of Molecular Erosion?

This erosion is driven by continuous exposure to endogenous stressors, including oxidative stress from mitochondrial respiration and chronic inflammatory signaling. The primary mechanisms include insufficient DNA repair, decreased fidelity of protein synthesis, and the failure of cellular quality control systems like the proteasome and autophagy. Mitigating this process requires strategies that bolster antioxidant defenses and enhance the cell's inherent repair and clearance capabilities.

Molecular Erosion ∞ Area

Molecular Erosion

Meaning

Molecular Erosion is a conceptual term in longevity medicine that describes the progressive accumulation of damage at the cellular and subcellular level over time, representing a fundamental mechanism of biological aging. This encompasses the degradation of key macromolecules, such as DNA damage, telomere shortening, protein cross-linking, and the accumulation of lipofuscin. The resulting erosion compromises cellular function, tissue integrity, and organ reserve, driving age-related decline.