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Molecular Endocrinology Shifts

Meaning

Subtle yet profound alterations in the intracellular signaling pathways, gene expression patterns, and receptor dynamics that occur in response to changes in circulating hormone concentrations, whether endogenous or exogenous. These shifts represent the fundamental biological mechanism through which hormonal therapies exert their systemic effects at the cellular level, influencing processes like protein synthesis, cellular differentiation, and metabolic regulation. Understanding these molecular shifts is key to interpreting the clinical presentation of a patient on hormonal therapy.