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Molecular Conformation

Meaning

Molecular Conformation describes the specific three-dimensional spatial arrangement of the atoms within a molecule, a characteristic that is critically important for determining its chemical properties and biological activity. For hormones and peptide therapeutics, the precise folding and shape of the molecule dictates its ability to recognize and bind to its specific receptor site on a target cell. Maintaining the correct conformation is paramount for a drug’s efficacy; any change in this structure, such as denaturation or degradation, can render the molecule biologically inert or, worse, potentially harmful. This structural integrity is a primary concern in the storage and handling of complex hormonal compounds.