Molecular Communication Protocols describe the defined, systematic rules governing how signaling molecules, such as hormones, cytokines, and neurotransmitters, interact with their specific cellular receptors to transmit information across physiological systems. Adherence to these protocols ensures accurate signal transduction, which is the basis of endocrine homeostasis. Errors in these protocols result in cellular malfunction.
Origin
This concept is borrowed from information theory and systems biology, applying the rigor of communication networks to biological signaling. ‘Molecular’ grounds the concept in biochemistry, while ‘protocols’ emphasizes the required specificity and sequence of molecular interactions. It defines the language of endocrinology.
Mechanism
The operational mechanism involves ligand-receptor binding, followed by a precise cascade of secondary messenger activation or direct gene regulation. For instance, a steroid hormone must enter the cell, bind to its intracellular receptor, and then translocate to the nucleus to initiate specific gene transcription in a predictable sequence. This fidelity of communication is essential for coordinated physiological responses across tissues.
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