Molecular communication networks refer to the intricate, highly redundant systems of signaling molecules—including hormones, cytokines, growth factors, and neurotransmitters—and their corresponding receptors that facilitate information transfer between cells, tissues, and organ systems. This complex network governs all physiological processes, from gene expression to systemic homeostasis, and its integrity is essential for maintaining health and wellness. Disruptions within these networks are the biochemical basis for many endocrine and age-related diseases.
Origin
The concept is foundational to modern molecular biology and endocrinology, stemming from the realization that cells do not act in isolation but are constantly exchanging information via chemical messengers. The term network emphasizes the interconnected, systemic nature of these signaling pathways.
Mechanism
Communication is executed through diverse signaling modalities, such as endocrine (long-distance, blood-borne), paracrine (local, adjacent cell), and autocrine (self-signaling). Hormones bind to specific high-affinity receptors, initiating a cascade of intracellular events that ultimately modify cellular function, protein synthesis, or gene transcription. The robust nature of these networks allows for precise, coordinated physiological responses to internal and external stimuli.
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