The fundamental understanding of how molecular and cellular events, such as protein synthesis, signal transduction cascades, and gene expression, directly underlie and regulate higher-level cognitive processes like memory, learning, and consciousness. This perspective views cognition not just as a neurological event, but as a direct outcome of precise, orchestrated molecular biology within the neurons and glia. It is the biochemistry of thought.
Origin
This concept is deeply rooted in molecular neurobiology and the study of synaptic plasticity, particularly the work on long-term potentiation (LTP) and the molecular mechanisms of memory consolidation. It provides the essential bridge between biochemistry and psychology.
Mechanism
Molecular cognition is driven by the dynamic regulation of synaptic strength, which is mediated by the precise localization and modification of receptors and structural proteins at the synapse. Hormones and neurotrophic factors, such as BDNF, exert their influence by binding to receptors and initiating intracellular signaling pathways that directly alter gene expression, ultimately leading to the physical changes required for new learning and memory storage.
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