The advanced therapeutic concept of utilizing specific molecular agents, lifestyle modifications, and environmental cues to deliberately influence the expression of genes and the activity of cellular pathways, effectively reprogramming the organism toward a more youthful, resilient biological state. This approach targets the epigenetic and cellular machinery responsible for age-related decline and systemic dysfunction. It represents a paradigm shift from treating symptoms to optimizing the underlying biological code.
Origin
This term is an evolution of concepts from genetics, epigenetics, and systems biology, using the language of programming from computer science to describe the directed control of biological processes at the molecular level. It underscores the potential for intervention to alter the trajectory of biological aging.
Mechanism
The core mechanism involves modulating epigenetic tags, such as DNA methylation and histone modification, which control gene accessibility and expression without altering the underlying DNA sequence. Specific compounds, including certain nutrients and hormones, can act as epigenetic modulators, influencing pathways like DNA repair, mitochondrial function, and cellular senescence, thereby encoding a more robust and resilient systemic response to stress and aging.
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