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Molecular Aging

Meaning

Molecular Aging refers to the cumulative, progressive accumulation of damage and dysfunction at the cellular and subcellular level that underlies the visible and functional decline of the human body over time. This includes quantifiable changes to DNA, proteins, lipids, and organelles, which collectively impair cellular homeostasis and regenerative capacity. Key hallmarks of this process include telomere shortening, epigenetic alterations, and mitochondrial decay, representing the fundamental biological basis of senescence. Understanding this molecular foundation is crucial for developing targeted longevity interventions.