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Molecular Accommodation

Meaning

Molecular accommodation describes the dynamic, adaptive changes that occur at the cellular or receptor level in response to the sustained presence or absence of a specific signaling molecule, such as a hormone or drug. This physiological adjustment can manifest as a change in receptor affinity, receptor number (up- or down-regulation), or the efficiency of the downstream intracellular signaling cascade. Understanding this accommodation is crucial for preventing therapeutic tolerance and maintaining the long-term efficacy of hormone replacement therapies.