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MK-0677

Meaning

MK-0677, also known as Ibutamoren, is a potent, non-peptide, orally active secretagogue that stimulates the secretion of Growth Hormone (GH) by mimicking the action of the endogenous hormone ghrelin. It functions by binding to the ghrelin receptor (GHS-R1a) in the brain, thereby increasing the pulsatile release of GH and subsequently elevating Insulin-like Growth Factor 1 (IGF-1) concentrations without significantly affecting cortisol levels. Clinically, its exploration has centered on its potential for increasing lean body mass, improving bone density, and enhancing sleep quality.