What is the Origin of Mitophagy Process?

This term is derived from Greek roots: 'mito' (thread, referring to mitochondria), 'phagy' (eating), and its function as a cellular process. Its recognition as a distinct regulatory mechanism became prominent with advances in cell biology studying organelle turnover.

What is the Mechanism of Mitophagy Process?

When mitochondrial membrane potential drops, specific receptor proteins like PINK1 accumulate on the outer membrane, recruiting the E3 ubiquitin ligase Parkin. Parkin then ubiquitinates outer membrane proteins, serving as an eat-me signal recognized by the autophagic machinery. The targeted organelle is then sequestered into an autophagosome which fuses with a lysosome for degradation and component recycling.

Mitophagy Process ∞ Area

Mitophagy Process

Meaning

The Mitophagy Process is the specialized form of macroautophagy dedicated to the selective removal and recycling of compromised mitochondria from the cell cytoplasm. This essential housekeeping function prevents the propagation of cellular damage caused by inefficient or stressed mitochondria which leak excessive reactive oxygen species. It is a cornerstone of cellular quality control.