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Mitochondrially-Derived Peptides

Meaning

Mitochondrially-Derived Peptides (MDPs) are a family of small, biologically active peptide molecules encoded by specific genes located within the mitochondrial DNA (mtDNA), representing a unique class distinct from the vast majority of proteins encoded by nuclear DNA. These peptides, which include molecules like Humanin and MOTS-c, function as novel signaling molecules, often acting outside the mitochondria to influence systemic metabolic processes and cellular stress responses. They represent an emerging and exciting class of endogenous regulators with profound implications for metabolic health, cellular resilience, and longevity.