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Mitochondrial Toxicity

Meaning

Mitochondrial toxicity is a clinical and cellular state characterized by damage to the mitochondria, the cell’s primary energy-producing organelles, resulting in impaired cellular respiration and energy production. This damage is often induced by exposure to various pharmacological agents, environmental toxins, or excessive oxidative stress. The resulting bioenergetic deficit can profoundly affect high-energy demand organs like the brain, heart, and endocrine glands. Clinically, mitochondrial toxicity can manifest as fatigue, metabolic dysfunction, and accelerated cellular aging, directly impacting hormonal signaling pathways.