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Mitochondrial Fuel Sourcing

Meaning

Mitochondrial Fuel Sourcing is the physiological and clinical process of optimizing the cellular pathways responsible for delivering and utilizing metabolic substrates—primarily fatty acids, glucose, and ketones—to the mitochondria for Adenosine Triphosphate (ATP) production. Efficient sourcing is crucial for maintaining a high bioenergetic state, which directly supports the energy-intensive processes of hormone synthesis, nerve conduction, and cellular repair. Dysregulated fuel sourcing is a hallmark of metabolic dysfunction and chronic fatigue. The goal is metabolic flexibility and sustained energy output.