Skip to main content

Mitochondrial Fidelity

Meaning

Mitochondrial fidelity refers to the robust, multi-layered system of quality control mechanisms that ensure the structural integrity, functional efficiency, and genetic accuracy of the mitochondria within a cell. High fidelity is characterized by minimal accumulation of mitochondrial DNA (mtDNA) mutations, efficient energy production (ATP synthesis), and a balanced network of fission and fusion dynamics. Preserving this fidelity is considered a fundamental pillar of cellular longevity and a critical factor in preventing age-related neurodegenerative and metabolic diseases.