A therapeutic and nutritional strategy aimed at enhancing the efficiency and capacity of the mitochondria, the cell’s primary energy generators, to synthesize Adenosine Triphosphate (ATP). This support is vital for sustaining high-level physiological function, as mitochondrial dysfunction is a primary driver of cellular senescence and age-related decline. Optimizing this process is key to vitality. Deficient energy production underlies much of age-related fatigue.
Origin
This concept stems from cellular bioenergetics and the free radical theory of aging, which identifies mitochondrial health as a central factor in longevity and chronic disease. The realization that age diminishes mitochondrial density and function spurred the development of targeted support protocols. Research into biogenesis and quality control mechanisms has been instrumental.
Mechanism
Support is achieved by providing key cofactors and substrates necessary for the electron transport chain and the Krebs cycle, such as Coenzyme Q10, B vitamins, and specific amino acids. Hormonal signals, including thyroid hormone and certain sex steroids, also act as powerful transcriptional regulators that promote mitochondrial biogenesis, thereby increasing the cellular capacity for aerobic respiration and energy output. Enhanced function leads to greater systemic energy availability.
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