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Mitochondrial Energy Impairment

Meaning

Mitochondrial Energy Impairment refers to a reduction in the efficiency or capacity of the mitochondria, the cell’s primary energy producers, to generate Adenosine Triphosphate (ATP) through oxidative phosphorylation. This cellular dysfunction is a hallmark of aging and numerous chronic diseases, leading to systemic fatigue, reduced organ function, and increased oxidative stress. The impairment can stem from structural damage, genetic mutations, or a failure in the quality control mechanisms that clear damaged organelles. Correcting this impairment is a central strategy in metabolic and longevity medicine to restore cellular vitality.