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Mitochondrial Drift Mitigation

Meaning

Mitochondrial Drift Mitigation is the clinical and biological strategy focused on slowing or reversing the age-related decline in mitochondrial function and genetic integrity, often referred to as mitochondrial drift. This degradation involves a decrease in the efficiency of the electron transport chain, an increase in reactive oxygen species production, and the accumulation of somatic mutations in mitochondrial DNA (mtDNA). Mitigation efforts aim to preserve the number, health, and functional capacity of these organelles, which are essential for cellular energy production and overall metabolic health. Preserving mitochondrial integrity is fundamental to longevity.