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Mitochondrial Biogenesis Impairment

Meaning

A pathological reduction in the rate of synthesis of new mitochondria, the cellular organelles responsible for generating the vast majority of the body’s energy (ATP), leading to a decreased total mitochondrial mass and functional capacity within high-energy-demand tissues like muscle, heart, and brain. This impairment is a core feature of biological aging and metabolic disease, resulting in chronic fatigue, reduced physical endurance, and diminished cognitive function. It represents a failure in the cellular renewal process.