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Mitochondrial Autophagy

Meaning

Mitochondrial autophagy, often termed mitophagy, is a highly specific and selective cellular quality control process responsible for the degradation and removal of damaged or dysfunctional mitochondria. This specialized form of autophagy is essential for maintaining a healthy population of mitochondria, the cellular powerhouses, thereby preventing the accumulation of reactive oxygen species and preserving cellular energy production. A decline in mitophagy efficiency is strongly associated with cellular senescence, metabolic dysfunction, and age-related endocrine disorders. Optimizing this process is a key target for longevity and healthspan interventions.