Question 1

What is the Meaning of MiR-22-3p?

Accepted Answer

A specific microRNA molecule, denoted as miR-22-3p, which is a small, non-coding RNA that plays a significant regulatory role in post-transcriptional gene expression. These microRNAs function as fine-tuners of cellular pathways by binding to complementary sequences on messenger RNA (mRNA) transcripts, leading to their degradation or translational repression. MiR-22-3p is a subject of intense research due to its involvement in various physiological and pathological processes, including cellular senescence, cardiac hypertrophy, and hormonal regulation.

Question 2

What is the Origin of MiR-22-3p?

Accepted Answer

This scientific term is derived from molecular genetics and is part of the nomenclature system for microRNAs, a class of molecules discovered in the early 1990s. The "MiR" stands for microRNA, while "22" denotes its specific number in the catalog of identified microRNAs. The "-3p" suffix indicates that the mature, functional microRNA strand is derived from the 3-prime arm of the hairpin precursor molecule.

Question 3

What is the Mechanism of MiR-22-3p?

Accepted Answer

The regulatory mechanism of miR-22-3p involves its incorporation into the RNA-induced silencing complex (RISC), which then guides the complex to specific target mRNA molecules. By binding to the 3' untranslated region (3'-UTR) of its target mRNAs, miR-22-3p suppresses the production of the corresponding protein, thereby effectively downregulating gene expression. Through this mechanism, it can influence hormonal signaling pathways by repressing the expression of key receptor or enzyme genes.

MiR-22-3p

Meaning

Origin

Mechanism

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