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Mineralocorticoid Receptor Function

Meaning

Mineralocorticoid Receptor Function describes the specific biological role of the intracellular receptor that mediates the effects of mineralocorticoid hormones, predominantly aldosterone, primarily in the epithelial cells of the kidney, colon, and sweat glands. This receptor is a ligand-activated transcription factor that regulates gene expression essential for maintaining electrolyte balance, specifically sodium and potassium levels, and blood pressure homeostasis. Dysfunction in this receptor system can lead to serious cardiovascular and fluid balance abnormalities, highlighting its critical role in systemic fluid and pressure regulation.