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Mineralocorticoid Receptor Antagonists

Meaning

Mineralocorticoid Receptor Antagonists (MRAs) are a specific class of pharmacological agents that function by competitively binding to and blocking the mineralocorticoid receptor in target tissues, primarily the renal collecting ducts and cardiovascular cells. Their primary clinical utility is in counteracting the effects of excessive aldosterone, a potent mineralocorticoid. These drugs are essential in the management of conditions characterized by volume overload, hypertension, and electrolyte imbalance, such as primary hyperaldosteronism and chronic heart failure. They represent a critical intervention in clinical endocrinology.