Question 1

What is the Meaning of mIGF-1?

Accepted Answer

mIGF-1, or Mechano-Growth Factor, is a specific splice variant of Insulin-like Growth Factor 1 (IGF-1), which is an anabolic polypeptide hormone with high structural homology to insulin. This localized variant is produced primarily in muscle tissue in response to mechanical strain or damage. It functions as a potent autocrine and paracrine factor, promoting tissue repair and local growth.

Question 2

What is the Origin of mIGF-1?

Accepted Answer

The Insulin-like Growth Factor family was initially named for its structural and functional similarity to insulin, playing a pivotal role in growth and metabolism. The specific splice variant, Mechano-Growth Factor, was identified and named for its unique, mechanical-stimulus-dependent expression pattern, distinguishing it from the systemic, liver-derived IGF-1. Its study is a specialized area within endocrinology and exercise physiology, focusing on tissue-specific repair and regeneration.

Question 3

What is the Mechanism of mIGF-1?

Accepted Answer

The primary mechanism involves the local expression of mIGF-1 in mechanically stressed tissue, such as skeletal muscle, where it is not subject to the same negative feedback regulation as systemic IGF-1. It binds to the Type 1 IGF receptor, activating a complex intracellular signaling cascade, including the PI3K/Akt pathway, which is a master regulator of cell survival and proliferation. This action potently stimulates muscle cell differentiation and protein synthesis, promoting localized tissue hypertrophy and repair.

mIGF-1

Meaning

Origin

Mechanism

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