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Midlife Hormone Initiation

Meaning

Midlife Hormone Initiation refers to the clinical strategy of commencing hormone replacement therapy, such as estrogen, progesterone, or testosterone, during the perimenopausal or early postmenopausal period, typically in the late forties or early fifties, coinciding with the first noticeable decline in endogenous hormone production. This early, timely intervention aims to mitigate the adverse long-term health consequences of hormone deficiency and is often associated with a more favorable risk-benefit profile. It is a critical component of preventative longevity medicine.