What is the Origin of MicroRNA Expression?

The term originates from the field of molecular biology and genetics, specifically with the discovery of the first microRNA in the nematode C. elegans in the early 1990s. It combines "micro" for its small size with "RNA expression" for the process of its biological activity.

What is the Mechanism of MicroRNA Expression?

MicroRNAs operate by binding to complementary sequences, usually in the 3' untranslated region (3'-UTR) of target messenger RNA molecules. This binding event prevents the ribosome from translating the mRNA into a protein or marks the mRNA for degradation. Consequently, microRNA expression provides a sophisticated, fine-tuning mechanism for controlling protein levels without altering the underlying DNA sequence.

MicroRNA Expression

Meaning

MicroRNA expression refers to the biological process of transcribing and utilizing small, non-coding RNA molecules, typically about 22 nucleotides long, known as microRNAs (miRNAs or miRs). These molecules do not code for proteins but instead function as powerful post-transcriptional regulators of gene expression. The precise pattern and quantity of microRNA expression in a cell determine which messenger RNAs (mRNAs) are suppressed or degraded, fundamentally influencing cellular fate and function.

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MicroRNA Expression

Meaning

Origin

Mechanism

How Do Lifestyle Choices Influence Epigenetic Markers Related to Hormonal Health?

Which Specific Lab Tests Can Measure My Personal Epigenetic Response to Lifestyle Changes?

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