What is the Origin of Microglia Modulation?

The term derives from immunology and neuroscience, where 'Microglia' are the brain's primary phagocytic cells, and 'Modulation' implies fine-tuning their activation state. Hormonal factors, including neurosteroids, are potent regulators of microglial polarization.

What is the Mechanism of Microglia Modulation?

Modulation occurs through altering the microglial signaling environment, often by reducing circulating

Microglia Modulation ∞ Area

Microglia Modulation

Meaning

Microglia Modulation refers to the deliberate influencing of the resident immune cells of the central nervous system, the microglia, to shift their functional phenotype from a pro-inflammatory, reactive state to a homeostatic, surveillance state. This modulation is critical because chronic microglial activation is implicated in neurodegeneration and cognitive decline, processes often exacerbated by systemic hormonal imbalances. We aim to maintain neuro-immune tranquility.