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Microglia Cell Activation

Meaning

This describes the transition of microglia, the resident immune cells of the central nervous system, from a quiescent, surveillance state to an active, phagocytic, or pro-inflammatory phenotype in response to injury, infection, or chronic neuroinflammation. While essential for clearing cellular debris and maintaining synaptic health, chronic or excessive activation of these cells is a key pathological driver in neurodegenerative diseases and is often linked to systemic hormonal imbalance. The degree and nature of Microglia Cell Activation are critical determinants of brain health and cognitive longevity.