What is the Origin of Microdosing?

The term is a compound of micro- (small) and dosing (the act of administering a dose). While the concept of using small doses is ancient, the term microdosing has gained contemporary relevance in both hormonal health, where it may be used to smooth out peaks and troughs, and in the context of certain compounds to enhance cognitive function without intoxication.

What is the Mechanism of Microdosing?

The proposed mechanism relies on the principle of receptor occupancy and gentle, non-saturating stimulation. By administering a very low dose, the substance may occupy a small percentage of its target receptors, providing a continuous, low-level signal that avoids the body's typical homeostatic counter-regulation or acute side effects associated with high receptor saturation. In hormonal therapy, this can result in more stable circulating levels and reduced conversion to downstream metabolites.

Microdosing

Meaning

Microdosing, in a pharmacological context, refers to the clinical practice of administering very small, sub-therapeutic doses of a substance, typically a hormone or a psychoactive compound, that are significantly lower than the standard clinical dose. The intent is to achieve subtle physiological or psychological effects without triggering the full, acute pharmacological response or side effect profile. This strategy aims to gently modulate an endocrine or neurological system over time.

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