Microbiome testing is a clinical diagnostic procedure used to analyze the composition and functional potential of the microbial communities residing in a specific human habitat, most commonly the gut. The data generated provides an objective assessment of microbial balance, biodiversity, and the presence of key beneficial or pathogenic species. This information is a foundational tool in functional medicine for addressing root causes of hormonal and metabolic dysfunction.
Origin
The term is a simple combination of “microbiome,” the collective microorganisms, and “testing,” the act of clinical assessment. Its emergence is a direct result of the scientific realization that the microbiome is an essential, modifiable component of human physiology. Clinical application allows for personalized strategies to optimize this ecosystem for better overall health outcomes.
Mechanism
Testing typically involves collecting a biological sample, such as stool, followed by DNA extraction and sequencing of marker genes, like the 16S rRNA gene, or whole-genome shotgun sequencing. The resulting sequence data is processed computationally to identify and quantify the different microbial taxa present. Clinicians then interpret these results in the context of hormonal pathways, looking for imbalances like dysbiosis or deficiencies in beneficial metabolite producers.
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