Skip to main content

Microbiome-Endocrinome Axis

Meaning

The Microbiome-Endocrinome Axis is the complex, bidirectional communication pathway that links the gut microbiota—the vast community of microorganisms residing in the gastrointestinal tract—with the host’s entire endocrine system, encompassing all hormone-producing glands and their secreted signaling molecules. This axis functions as a crucial regulatory hub where microbial metabolites directly or indirectly influence host hormone production, receptor expression, and overall metabolic and neuroendocrine homeostasis. Dysbiosis within this axis is a recognized contributor to systemic hormonal imbalances and chronic disease pathology.