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Microbiome Endocrine Modulation

Meaning

Microbiome Endocrine Modulation describes the direct and indirect regulatory influence exerted by the resident microbial communities on the host’s hormonal signaling systems. This complex, bidirectional communication involves microbial production of hormone-mimicking substances, enzymatic modification of host hormones, and modulation of hormone receptor expression and sensitivity. The gut microbiota’s metabolic activity profoundly impacts the bioavailability and systemic effect of steroid hormones, thyroid hormones, and neuropeptides. This modulatory capacity is a crucial factor in maintaining systemic hormonal balance and overall metabolic fitness.