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Microbiome Derived GABA

Meaning

Microbiome Derived GABA defines the inhibitory neurotransmitter Gamma-Aminobutyric Acid (GABA) that is synthesized and released by specific species of commensal bacteria residing within the gastrointestinal tract. While the majority of circulating GABA does not cross the blood-brain barrier, this gut-derived pool acts locally within the enteric nervous system, influencing gut motility and sensation, and potentially signaling to the central nervous system via the vagus nerve. This production highlights the gut’s direct role in neurochemical balance.