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Microbial Signaling Pathways

Meaning

Microbial Signaling Pathways are the complex biochemical communication routes through which the diverse gut microbiota profoundly influences host physiology, primarily by producing and systematically releasing bioactive metabolites that interact with host cell receptors and genetic machinery. These crucial pathways involve the systemic transport and specific action of compounds like Short-Chain Fatty Acids, secondary bile acids, and various tryptophan derivatives, which function as critical messengers between the microbial world and the host’s essential endocrine, immune, and nervous systems. These constant, dynamic signals are vital for maintaining systemic host homeostasis and adaptive capacity.