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Microbial Metabolic Signaling

Meaning

Microbial metabolic signaling describes the complex chemical communication system mediated by the bioactive metabolites produced by the gut microbiota that interact directly with host cells and distant organs. These small molecules, including short-chain fatty acids, neurotransmitter precursors, and modified host compounds, act as crucial ligands for host receptors, modulating gene expression, immune function, and endocrine secretion. This signaling pathway is a primary mechanism through which the gut microbiome influences systemic health, mood, and the overall hormonal environment. It represents a fundamental layer of inter-species biological regulation.