Microbial Ecosystem Intelligence refers to the complex, emergent regulatory capacity exhibited by a diverse and balanced gut microbial community to influence host physiology far beyond simple digestion. This intelligence manifests in the coordinated production of signaling molecules that interface directly with endocrine and neurological systems. We view the microbiome not as passive passengers but as active regulators of host homeostasis. This collective function guides systemic adaptation.
Origin
This term elevates the description of the microbiome from a collection of organisms to a functional, intelligent system, analogous to distributed computing networks. Intelligence implies adaptive response and complex signaling coordination. It acknowledges the profound impact of microbial community structure on host survival mechanisms.
Mechanism
The microbial community exerts its influence by producing a vast array of signaling metabolites, including short-chain fatty acids and secondary bile acids, which interact with host receptors like G-protein coupled receptors (GPCRs). These interactions modulate host satiety signals, inflammatory tone, and even the efficiency of hepatic steroid metabolism. This complex signaling network effectively steers host metabolic fate.
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