The intentional and scientifically guided manipulation of the gut microbiota’s composition and function to produce specific, measurable, and beneficial physiological outcomes for the host. This represents a precision approach to microbiome therapeutics.
Origin
This advanced concept is rooted in systems biology and the increasing ability to sequence and analyze the complex gut microbiome. “Engineering” signifies a deliberate, predictable intervention to modify the biological system, moving beyond simple supplementation.
Mechanism
Engineering strategies involve personalized administration of targeted probiotics, specific prebiotics to feed beneficial keystone species, or even advanced fecal microbiota transfer. The goal is to optimize the production of beneficial postbiotics, such as short-chain fatty acids (SCFAs), which are vital for immune modulation and neuroendocrine signaling. This targeted modification is crucial for enhancing overall systemic vitality.
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