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Microarchitectural Deterioration

Meaning

Microarchitectural Deterioration describes the structural breakdown and degradation of the fine internal scaffolding of a tissue, most commonly referring to the trabecular bone network. This process involves the thinning and loss of connectivity of the trabeculae, significantly compromising the overall strength and resilience of the bone structure, leading to increased fracture risk. In hormonal health, this deterioration is a hallmark of conditions like osteoporosis, often accelerated by estrogen cessation or chronic glucocorticoid excess. Assessing and mitigating this structural decline is a key objective in maintaining skeletal integrity and longevity.