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Methylenetetrahydrofolate Reductase

Meaning

Methylenetetrahydrofolate Reductase (MTHFR) is a crucial enzyme in the human body responsible for converting 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate (5-MTHF), the active form of folate. This active folate is a necessary co-factor for the methylation cycle, a biochemical process essential for DNA synthesis, repair, and the metabolism of neurotransmitters and hormones. Clinically, genetic polymorphisms in the MTHFR gene can reduce the enzyme’s activity, potentially impairing the body’s ability to detoxify certain compounds and properly regulate hormonal balance. Assessing MTHFR status is a key part of personalized nutritional and hormonal support.